Giant fixed drug eruption
How to cite this article: Kantaria SM, Kantaria DS. Giant fixed drug eruption. Indian J Skin Allergy. doi: 10.25259/IJSA_47_2023
A 29-year-old male presented with a solitary, well-circumscribed, oval-shaped, dark-violaceous pruritic giant patch with an erythematous border measuring 26 × 14 cm in size on the right lateral side of his abdomen. There were vesiculation and distinct spared areas against a background of dusky, violaceous erythema at the center of the lesion [Figure 1]. He developed the eruption within 2 h after taking a single dose of cotrimoxazole. Based on typical clinical morphology, a diagnosis of fixed drug eruption (FDE) was made. The patient was subjected to an oral provocation test, and after giving one-fourth tablet of cotrimoxazole, reactivation of the healed lesion was observed within 2 h. Fluoroquinolones, sulfonamides, tetracyclines, and non-steroidal anti-inflammatory drugs are common causes of FDEs. In a study, the ofloxacin-ornidazole fixed drug combination was responsible for the greatest number of cases of FDE. Although FDEs are very common, such giant patches are rare.
The Institutional Review Board approval is not required.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent.
Conflicts of interest
There are no conflicts of interest.
Use of artificial intelligence (AI)-assisted technology for manuscript preparation
The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI.
Financial support and sponsorship