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Giant fixed drug eruption
*Corresponding author: Shailesh Mohanbhai Kantaria, Department of Dermatology, Kantaria Skin Clinic, Porbandar, Gujarat, India. kantariashailesh@yahoo.in
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Received: ,
Accepted: ,
How to cite this article: Kantaria SM, Kantaria DS. Giant fixed drug eruption. Indian J Skin Allergy. 2024;3:83. doi: 10.25259/IJSA_47_2023
A 29-year-old male presented with a solitary, well-circumscribed, oval-shaped, dark-violaceous pruritic giant patch with an erythematous border measuring 26 × 14 cm in size on the right lateral side of his abdomen. There were vesiculation and distinct spared areas against a background of dusky, violaceous erythema at the center of the lesion [Figure 1]. He developed the eruption within 2 h after taking a single dose of cotrimoxazole. Based on typical clinical morphology,[1] a diagnosis of fixed drug eruption (FDE) was made. The patient was subjected to an oral provocation test, and after giving one-fourth tablet of cotrimoxazole, reactivation of the healed lesion was observed within 2 h. Fluoroquinolones, sulfonamides, tetracyclines, and non-steroidal anti-inflammatory drugs are common causes of FDEs. In a study, the ofloxacin-ornidazole fixed drug combination was responsible for the greatest number of cases of FDE.[2] Although FDEs are very common, such giant patches are rare.
- Giant patch of fixed drug eruption.
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Declaration of patient consent
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Conflicts of interest
There are no conflicts of interest.
Use of artificial intelligence (AI)-assisted technology for manuscript preparation
The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI.
Financial support and sponsorship
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References
- Fixed drug eruption. A brief review. Arch Dermatol. 1984;120:520-4.
- [CrossRef] [PubMed] [Google Scholar]
- Retrospective analysis of fixed drug eruptions among patients attending a tertiary care centre in Southern India. Indian J Dermatol Venereol Leprol. 2014;80:194.
- [CrossRef] [PubMed] [Google Scholar]
